MRI Screening for Breast Cancer Benefits High-Risk, Underserved Women

Using breast magnetic resonance imaging (MRI) screenings among targeted, high-risk, underserved women considerably decreases diagnostic cost and increases patient compliance rates with follow-up compared to using just general risk mammography screenings.

However, a caveat to these findings was that the cost of a MRI scan was reduced from an average of US$3,500 to $649 by a grant specific to the study. Cost per diagnosis was $37,375 for mammography compared to $21,561 for MRI at the grant-based rate, according to the researchers. “What we need is to lower the cost of MRI, and maybe that will happen as we do more of them,” said lead researcher Anne C. Ford, MD, assistant professor in obstetrics and gynecology at Duke University Medical Center (Durham, NC, USA).

Early findings of the study, conducted by Dr. Ford and colleagues from 2004 to 2011, were presented at the Fourth American Association for Cancer Research (AACR) Conference on The Science of Cancer Health Disparities, held in Washington DC (USA) from September 18-21, 2011.

The researchers compared breast cancer mammography screening in 299 general risk, underserved women to MRI screening in 299 high-risk, underserved women. Women with abnormal mammogram or abnormal breast MRI underwent ultrasound, ultrasound guided biopsy and/or stereotactic biopsy for mammogram cases, and/or MRI-guided biopsy for MRI cases.

Results showed that mammographic screenings detected one breast cancer case, while MRI screenings detected nine cases. Benign breast/total biopsies were found in 88% of mammographic screening cases and in 78% of MRI cases. “In an underserved population, using this model, it is cost effective to screen with MRI because we found more breast cancers with MRI than we did with mammography in this population,” Dr. Ford said. “If you truly target high-risk women with MRIs, you can find the cancers, and you can find them early.”

Moreover, compliance with follow-up in mammographic screenings was 75% and 90% in MRI screenings. Critical to those findings was the utilization of a breast navigation team, which recruited study participants from the general population at health and screening fairs in central North Carolina (USA), according to Dr. Ford. “The navigation team was key in helping the women--and these are all uninsured or under-insured women--negotiate the medical center,” she said.

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Duke University Medical Center